Relation of 11 C-MET uptake in PET with cell proliferation and angiogenesis in human brain gliomas
10.3969/j.issn.1671-8348.2013.30.006
- VernacularTitle:人脑胶质瘤 PET 成像中11C-蛋氨酸摄取与细胞增殖和血管形成的关系
- Author:
Haining ZHEN
;
Nobuyuki KAWAI
;
Shuichi OKUBO
;
Zhou FEI
;
Xiang ZHANG
;
Weiping LIU
;
Junli HUO
;
Takashi TAMIYA
- Publication Type:Journal Article
- Keywords:
positron emission tomography;
11 C-methionine;
cell proliferation;
neovascularization,pathologic;
glioma
- From:
Chongqing Medicine
2013;(30):3606-3609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation of 11C-methionine (11C-MET) uptake with cell proliferation and angiogenesis in human brain gliomas .Methods For 30 cases of newly diagnosed glioma patients ,positron emission tomography (PET ) examina-tion with 11C-MET was performed ,and the maximal standardized uptake value (SUVmax) of 11C-MET was measured .Expression of Ki-67 and CD34 antigens was examined by immunohistochemistry method in the same glioma samples ,both Ki-67 labeling index (Ki-67 LI) and microvessel density (MVD) were measured .Results Both 11C-MET SUVmax and Ki-67 LI increased significantly with glioma pathological grade ascending (P=0 .000 ,P=0 .000) ,and which in malignant glioma tissues were significantly higher than those in benign glioma tissues as well (P=0 .000 ,P=0 .000);however ,there were not significant differences in MVD among different grades of gliomas (P=0 .831) as well as between high and low malignant gliomas (P=0 .370) .11 C-MET SUVmax was significantly positively correlated with Ki-67 LI (P= 0 .000) ,however ,there were not significant correlations between 11C-MET SUVmax and MVD (P=0 .154) as well as between Ki-67 LI and MVD (P=0 .842) .Conclusion 11C-MET uptake and cell prolif-eration activity can better reflect the pathological grades and malignant degrees of gliomas .
