Therapeutic Effect Assessment Indexes of Randomized Controlled Trials on Traditional Chinese Medicine Syndrome Differentiation and Treatment of Chronic Obstructive Pulmonary Disease：A Systematic Review
10.11842/wst.2013.06.031
- VernacularTitle:中医药辨证治疗慢性阻塞性肺疾病稳定期随机对照试验的疗效评价指标系统评价
- Author:
Hailong ZHANG
;
Minghang WANG
;
Dongliang ZHAO
;
Xueqing YU
;
Haifeng WANG
;
Jiansheng LI
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
stable phase;
traditional Chinese medicine;
systematic review;
randomized controlled trials;
therapeutic effect assessment index
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(6):1416-1424
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to review of the selection and use of the therapeutic effect assessment indexes of randomized controlled trials ( RCTs ) on traditional Chinese medicine ( TCM ) syndrome differentiation and treatment of chronic obstructive pulmonary disease ( COPD ) based on clinical efficacy . Published studies were searched in the CBM , CNKI , VIP , Wanfang database , Cochrane Library , PubMed and Embase to identity all RCTS on TCM treatment of COPD . Two researchers selected studies and extracted data independently using a designed extraction form . The Cochrane collaboration software RevMan 5 . 1 was used for meta-analysis . The re-sults showed that a total of 40 RCTs were included . Meta-analyses showed that TCM syndrome differentiation and treatment of COPD can improve the pulmonary function and life quality , improve the clinical effect and TCM syndrome effect , reduce the number of acute exacerbation of COPD and improve clinical symptoms . Some therapeutic effect assessment indexes , such as pulmonary function , life quality , clinical comprehensive effect , the number of acute exacerbation of COPD, clinical symptoms and signs, syndrome effect and the integral of syndrome were used more frequent . Other indexes such as 6-min walk distance , BODE Index and health eco-nomic evaluation were used less frequently . It was concluded that TCM syndrome differentiation and treatment of COPD had certain therapeutic efficacy. A large number of strictly-designed, multicenter, high-quality RCTs are required because of the low quality of the included studies. The selection of therapeutic effect assessment indexes is still not standardized . The therapeutic effect assessment indexes should be selected based on differ-ent purposes of clinical studies with the clinical characteristics of TCM .
