The Expression of CTGF in Condyle Cartilage under Asymmetric Masticatory Force
- VernacularTitle:不对称咀嚼力作用下CTGF在髁突软骨中的表达
- Author:
Lingling LI
;
Tao NI
;
Song LI
;
Yingwei LUO
- Publication Type:Journal Article
- Keywords:
Masticatory force;
CTGF;
Condylar cartilage;
Remodeling
- From:
Journal of Kunming Medical University
2013;(10):22-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the asymmetric of masticatory force on the remodeling of bilateral mandibular condylar cartilage of SD rats. Methods The animal models were established respectively by excising the unilateral temporalis, and injecting botulinum toxin A into the unilateral masseter. Dividing three batch processing 3 weeks, 6 weeks, and 9 weeks after the animal modeling, six rats were killed in each group. The expression of CTGF in condylar cartilage was observed by immunohistochemical staining. Results CTGF expressed in proliferative layer,chondroblast layer and hypertrophic layer of the condylar cartilage. The expression of CTGF in the experimental groups was increased than control groups (<0.05) . There was no significant difference between the left and right side in the experimental groups ( >0.05), the expression of CTGF after 6 weeks of operation was stronger than the group after 3 weeks of operation, the expression of CTGF after 9 weeks of operation was the strongest than all of other groups ( <0.05) . Conclusions The asymmetric of masticatory force can up-regulate the expression of CTGF mRNA in rat mandibular condylar chondrocytes. CTGF induces the effect of stress-mediated on the mandibular condylar cartilage remodeling.
