The Expression of MCP-1 in the Diabetes Mellitus Skin Defect Healing
- VernacularTitle:糖尿病皮肤缺损愈合进程中单核细胞趋化蛋白-1表达的研究
- Author:
Shaoyun WANG
;
Xiang MA
;
Li ZHANG
;
Yanbin XIAO
;
Xiang ZHANG
- Publication Type:Journal Article
- Keywords:
MCP-1;
The diabetes mellitus skin;
Healing
- From:
Journal of Kunming Medical University
2013;(9):51-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of MCP-1 in the diabetes mellitus skin defect healing, then discuss its effect. Methods The diabetes mellitus models were established, and the expression of MCP-1 was detected by immunohistochemical staining and Elisa. Results The immunohistochemistry stain showed that the expression of MCP-1 in DM group was higher than that in control group at all time. And the serum value of MCP-1 in DM group had statistical significance ( <0.05) at 3 days or 1 week, but that in 2 weeks and 4 weeks was no statistical significance ( <0.05) . Conclusion The MCP-1 might play a role in the healing of diabetes mellitus skin defect through mediate abnormal inflammatory response.
