Association of ApoB/ApoA-1 Ratio with Insulin Resistance in Patients with Non-alcoholic Fatty Liver Disease
- VernacularTitle:非酒精脂肪肝病患者ApoB/ApoA1比值与胰岛素抵抗的相关性研究
- Author:
Lixin SHEN
;
Jun HOU
;
Qiangpeng WU
;
Hongrong WANG
;
Yuan XIA
;
Lirong ZHU
;
Yanping DUAN
- Publication Type:Journal Article
- Keywords:
Non-alcoholic fatty liver disease;
ApoB/apoA-1 ratio;
Insulin resistance
- From:
Journal of Kunming Medical University
2013;(9):69-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aims to investigate the association of apoB/apoA-1 ratio with insulin resistance (IR) in patients with non-alcoholic fatty liver disease (NAFLD) . Methods A total of 224 patients with NAFLD and 166 healthy subjects were enrolled as NAFLD group and control group. Weight, height and blood pressure were recorded. Serum levels of fasting blood glucose (FPG), insulin (Fins), lipids, glycated hemoglobin (HbA1c) were measured. Homeostasis model assessment-insulin resistance (HOMA-IR) indices were calculated. Results Compared with control group, NAFLD group had higher apoB/apoA-1 ratio (0.76 ± 0.28 vs 0.61 ± 0.26) and HOMA-IR (2.43 ± 1.68 vs 1.86 ± 1.61) . Spearman correlation analysis showed that in NAFLD group, HOMA-IR positively correlated with age, body mass index (BMI), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), apoB/apoA-1 ratio (r =0.34, P < 0. 05) and HbA1c, and negatively correlated with high-density lipoprotein cholesterol (HDL-c) . Multiple linear regression analysis revealed that apoB/apoA-1 ratio was still associated with HOMA-IR in NAFLD group after adjustment for age and BMI. Conclusion The apoB/apoA-1 ratio is closely associated with IR in patients with NAFLD. ApoB/apoA-1 ratio may play a role in the development of IR in NAFLD.
