Heparin-binding epidermal growth factor-like growth factor and necrotizing enterocolitis
10.3760/cma.j.issn.1673-4408.2013.06.013
- VernacularTitle:HB-EGF与坏死性小肠结肠炎的研究进展
- Author:
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
HB-EGF;
Necrotizing enterocolitis;
Intestine;
Injury
- From:
International Journal of Pediatrics
2013;40(6):585-588
- CountryChina
- Language:Chinese
-
Abstract:
Necrotizing enterocolitis(NEC) is a common and devastating gastrointestinal disease that occurs predominantly in premature infants.Despite various advances in management,the mortality of this disease remains high.During the last decade,studies have shown that heparin-binding epidermal growth factor-like growth factor (HB-EGF),can protect intestinal epithelial cells from various forms of injury in vitro.Furthermore,studies using both an intestinal ischemia-reperfusion injury model in adult rats and neonatal rat model of NEC,have shown that HB-EGF can protect the intestines from injury.Present studies provide a new research direction in the prevention and treatment.
