Advances in gray matter heterotopia in children
10.3760/cma.j.issn.1673-4408.2013.06.016
- VernacularTitle:儿童灰质异位症的研究进展
- Author:
Yanwen SHEN
- Publication Type:Journal Article
- Keywords:
Neuronal migration disorder;
Gray matter heterotopia
- From:
International Journal of Pediatrics
2013;40(6):596-598
- CountryChina
- Language:Chinese
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Abstract:
Gray matter heterotopias,which can be classified into subependymal heterotopia,subcortical heterotopia,band heterotopia and mixed heterotopia,belongs to neuronal migration disorders.Any factors including physical or chemical factors,biological factors and genetical factors that occur during neuronal migration phase can lead to gray matter heterotopias.The latest studies have revealed many genes are involved in the pathogenesis of gray matter heterotopias,especially in subependymal heterotopia and band heterotopia with their own characteristics.The main clinical disorders in pediatric heterotopias include developmental delay,epilepsy and motor disturbance.The diagnosis of the disease is made through neuroimaging examinations especially magnetic resonance imagings.The advanced magnetic techniques like magnetic resonance spectroscopy and functional magnetic resonance can be helpful in the final diagnosis.
