Expression and clinical signiifcance of Nusap1 in hepatical carcinoma
10.3969/j.issn.1672-7347.2013.09.002
- VernacularTitle:Nusap1蛋白在肝癌中的表达及其临床意义
- Author:
Meng ZHANG
;
Dinghua YANG
;
Xiao LIU
;
Yan LIU
;
Jiankun LIANG
- Publication Type:Journal Article
- Keywords:
hepatical carcinoma;
Nusap1;
immunohistochemistry
- From:
Journal of Central South University(Medical Sciences)
2013;38(9):876-881
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and clinical significance of Nusap1 in hepatical carcinoma. Methods:The expression of Nusap1 protein in 61 specimens of hepatical carcinoma was examined by immunohistochemistry. Based on the levels of Nusap1 expression, the 61 specimens were divided into a high Nusap1 expression group and a low Nusap1 expression group. The correlation between Nusap1 expression with clinicopathologic features and prognosis of hepatical carcinoma was analyzed. Results:TherateofhighNusap1expressionwas54.1%inhepaticalcarcinoma.TherateofhighNusap1 expression was 21.3%in noncarcinoma, with signiifcant difference between the 2 groups (P<0.01).Nusap1 overexpression had signiifcant correlation with histological differentiation, tumor size, liver cirrhosis,lymphaticmetastasis,tumorthrombiandearlyrecurrence(P<0.05),butnotwithsex,age,AFP level,tumornumber,TNMclassificationandtumorencapsulation(P>0.05).Survivalanalysissuggested thatthe6monthand12monthnoncarcinomasurvivalratewassignificantlylowerinthehighNusap1 expression group [33.3%(11/33), 17.9%(5/33)] than that in the low Nusap1 expression group [89.3%(25/28), 53.6%(15/28);P<0.005]. Conclusion:Nusap1 is overexpressed in hepatical carcinoma and is a valuable prognostic factor for hepatical carcinoma.
