F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy.
10.3348/kjr.2016.17.2.281
- Author:
Hyunjong LEE
1
;
Won Woo LEE
;
So Yeon PARK
;
Sang Eun KIM
Author Information
1. Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul 13620, Korea. wwlee@snu.ac.kr
- Publication Type:Brief Communication ; Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
Thyroid cancer;
Bone metastasis;
Bone scintigraphy;
F-18 sodium fluoride;
Positron emission tomography
- MeSH:
Adult;
Bone Neoplasms/*radiography/secondary;
Bone and Bones/*radiography;
Contrast Media/*chemistry;
Female;
Fluorine Radioisotopes/chemistry;
Humans;
Male;
Middle Aged;
Positron-Emission Tomography;
Retrospective Studies;
Sodium Fluoride/*chemistry;
Thyroid Neoplasms/*pathology;
Tomography, X-Ray Computed;
Whole Body Imaging
- From:Korean Journal of Radiology
2016;17(2):281-288
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The aim of the study was to compare the diagnostic performances of F-18 sodium fluoride positron emission tomography/computed tomography (bone PET/CT) and bone scintigraphy (BS) for the detection of thyroid cancer bone metastasis. MATERIALS AND METHODS: We retrospectively enrolled 6 thyroid cancer patients (age = 44.7 ± 9.8 years, M:F = 1:5, papillary:follicular = 2:4) with suspected bone metastatic lesions in the whole body iodine scintigraphy or BS, who subsequently underwent bone PET/CT. Pathologic diagnosis was conducted for 4 lesions of 4 patients. RESULTS: Of the 17 suspected bone lesions, 10 were metastatic and 7 benign. Compared to BS, bone PET/CT exhibited superior sensitivity (10/10 = 100% vs. 2/10 = 20%, p = 0.008), and accuracy (14/17 = 82.4% vs. 7/17 = 41.2%, p < 0.025). The specificity (4/7 = 57.1%) of bone PET/CT was not significantly different from that of BS (5/7 = 71.4%, p > 0.05). CONCLUSION: Bone PET/CT may be more sensitive and accurate than BS for the detection of thyroid cancer bone metastasis.
