Progress in tumor vascular normalization for anticancer therapy
10.3760/cma.j.issn.1006-9801.2013.09.022
- VernacularTitle:血管正常化在肿瘤治疗中的研究进展
- Author:
Di WANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Vascular normalization;
Therapy
- From:
Cancer Research and Clinic
2013;25(9):638-640
- CountryChina
- Language:Chinese
-
Abstract:
Blood vessels are indispensible for tumor growth and metastasis.Traditional antiangiogenic strategy reduce the density and the supply of tumor blood vessels.Recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy.Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues,which fosters tumor cells to become more aggressive and metastatic.Tumor vascular normalization may be an alternative approach to treat cancers,normalize the disorganized tumor vasculature,rather than disrupting or blocking them,thus reduce tumor hypoxia as well as increase the efficacy of chemotherapy,radiotherapy and immunotherapy.
