Attenuated and Synergistic Effect of Meteorism Tablets in Treatment of HBeAg-positive Chronic Hepatitis B
10.3969/j.issn.1005-5304.2013.11.004
- VernacularTitle:臌胀片在HBeAg阳性慢性乙型病毒性肝炎治疗中的减毒增效作用
- Author:
Huili WANG
;
Tianshu GAO
;
Xiaoping YANG
;
Yuyao ZHAO
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
HBeAg;
meteorism tablets;
telbivudine;
attenuated and synergistic effect
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(11):8-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the attenuated and synergistic effect of meteorism tablets in treating HBeAg-positive chronic hepatitis B patients. Methods Eighty patients of HBeAg-positive chronic hepatitis B were randomly divided into treatment group (meteorism tablets combined with telbivudine) and control group (telbivudine), and treated for one year. The changes of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the negative rate of HBV-DNA, the negative rate of HBeAg, HBeAg/HbeAb serological conversion rate, creatine kinase (CK) before and after treatment, and safety were observed. Results After treatment, biochemical response, virological response and HBeAg serological response was more significant in the treatment group than that in the control group (P<0.05). The percetage of patients with elevated CK in the treatment group was significantly lower than that in the control group (32.5% vs 60%, P<0.05). Conclusion Meteorism tablets combined with telbivudine has attenuated and synergistic effect in treating HBeAg-positive chronic hepatitis B patients.
