Mechanisms of action of intravenous immunoglobulin in autoimmune and inflammatory diseases
10.3760/cma.j.issn.1673-4408.2013.06.002
- VernacularTitle:静脉丙种球蛋白在自身免疫性及炎症性疾病中作用机制研究进展
- Author:
Jingjing CHEN
- Publication Type:Journal Article
- Keywords:
Intravenous immunoglobulin;
F (ab) 2 receptor;
Fc receptor;
Cytokine;
Adhesion molecule
- From:
International Journal of Pediatrics
2013;40(6):549-551
- CountryChina
- Language:Chinese
-
Abstract:
Intravenous immunoglobulin(IVIG) has been increasingly used in autoimmune and inflammatory diseases in the past 30 years.The effect of IVIG is obvious,but its mechanism of action is unclear.This review discusses the progresses in mechanism of action of IVIG in recent years,which include the F(ab) 2 and Fc receptor-mediated mechanisms of IVIG,modulation of adhesion molecules and cytokine production.We also discuss these mechanisms with respect to the different autoimmune and inflammatory diseases for which they might be relevant.
