Association between substance P and chronic prostatitis in rat model

VernacularTitle:大鼠前列腺组织P物质与慢性前列腺炎的相关性研究
Author: Yang SU ; Chaozhao LIANG ; Song FAN ; Xiang FANG
Publication Type:Journal Article
Keywords: Chronic protatitis; Neuroendocrine cells; Substance P
From: Chinese Journal of Urology 2013;34(11):855-858
CountryChina
Language:Chinese
Abstract: Objective To explore the correlation between prostate neuroendocrine cells and chronic prostatitis via substance P (SP) detection.Methods Forty SPF-level SD male rats in two months old were randomized into two groups:the chronic prostatitis model group and the control group,20 in each.The model was induced by castration surgery under aseptic condition and post-castration injection of 17-β estrogen for 1 month duration.The control group was done by injection of 0.9％ NS without castration surgery.Making sure that the chronic prostatitis model was made successfully,then SP quantification in the 2 groups was analyzed via ELISA and immunohistochemical staining.Results The difference of SP in the 2 groups was significant (P =0.009) and SP was expressed highly in the model rats compared with controls.Conclusion The relationship between prostate neuroendocrine cells and chronic prostatitis is notable,maybe they participate in progress of chronic prostatitis.