Clinical observation of inhalation combined salmeterol plus fluticasone propionate aerosol in treatment of asthma in preschool children
10.3760/cma.j.issn.1673-4408.2013.05.025
- VernacularTitle:沙美特罗替卡松气雾剂吸入治疗学龄前哮喘的临床观察
- Author:
Jianrong PAN
;
Zhiwei YU
;
Juanjuan XIE
- Publication Type:Journal Article
- Keywords:
Asthma;
Combined salmeterol plus fluticasone aerosol;
Preschool children
- From:
International Journal of Pediatrics
2013;40(5):529-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of inhalation combined salmeterol plus fluticasone propionate in treatment of asthma in children between 4 ～ 5 years old.Methods Seventy-four children (age range,4 ～ 5 years) were enrolled for our study,they were randomly divided into 2 groups (one group inhaled combined salmeterol plus fluticasone,37 children;the other group inhaled fluticasone,37 children).Comparative studies of clinical efficacy,quantified symptom score,and regular follow-up observations were conducted at the interval of one week,one month,three months.Results In the first week and first month during the treatment,there were no difference between salmeterol plus fluticasone group and fluticasone group (P ＞ 0.05).In the third month during the treatment,the daytime ratings(0.16 ± 0.09 vs 0.32 ± 0.11,P ＜ 0.05) and night ratings(0.04 ± 0.01 vs 0.14 ±0.00,P ＜0.05) of salmeterol plus fluticasone group were significantly better than those of fluticasone group.After three months,more children in salmeterol plus fluticasone group were responsive to the decreased dose of the drug than those of fluticasone group (x2 =4.57,P ＜ 0.05).Conclusion In the follow-up of exacerbatious,treatment with combined salmeterol and fluticasone propionate was as efficient as that of fluticasone in alleviating symptoms.During remission of asthma,combined salmeterol and fluticasone propionate was probably better than fluticasone for control of symptoms.
