Correlation of B-type natriuretic peptide levels and echocardiographic parameters in preterm infants with patent ductus arteriosus.
10.3345/kjp.2016.59.4.183
- Author:
Hyun Ah JEONG
1
;
Jeonghee SHIN
;
Eunji KIM
;
Eun Hee LEE
;
Byung Min CHOI
;
Chang Sung SON
;
Joo Won LEE
Author Information
1. Department of Pediatrics, Korea University College of Medicine, Seoul, Korea. cbmin@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Patent ductus arteriosus;
B-type natriuretic peptide;
Echocardiography;
Premature infant
- MeSH:
Ductus Arteriosus;
Ductus Arteriosus, Patent*;
Echocardiography*;
Humans;
Infant, Newborn;
Infant, Premature*;
Natriuretic Peptide, Brain*;
Plasma;
Pulmonary Artery
- From:Korean Journal of Pediatrics
2016;59(4):183-189
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study aimed to evaluate the correlation, according to postnatal age, between plasma B-type natriuretic peptide (BNP) levels and echocardiographic parameters for the assessment of patent ductus arteriosus (PDA) in preterm infants with respiratory distress. METHODS: We enrolled 42 preterm infants with respiratory distress who underwent serial echocardiographic evaluation with simultaneous plasma BNP measurements until ductal closure. The correlations between BNP levels and the following 4 representative echocardiographic parameters were studied: diameter of the ductus arteriosus (DA), ratio of the left atrial diameter to the aortic diameter (LA/Ao), ratio of the PDA diameter to the infant's left pulmonary artery diameter (PDA/LPA), and the antegrade diastolic flow of LPA (DFLPA). RESULTS: BNP levels were significantly correlated to the magnitude of the ductal shunt, comprising the DA diameter, PDA/LPA ratio, LA/Ao ratio, and antegrade DFLPA for the overall study period. The earliest significant correlation, starting from postnatal day 2, was observed between the LA/Ao ratio and BNP levels. The PDA/LPA ratio and the antegrade DFLPA showed significant correlations with BNP levels postnatal day 3 onward, and with the DA diameter, postnatal day 5 onward. CONCLUSION: BNP levels and echocardiographic parameters showed a positive correlation, but the significance of the correlations differed according to the postnatal age, especially during the first few days of life.
