Aquaporins and cancer
- VernacularTitle:水通道蛋白与肿瘤
- Author:
Hong ZHANG
;
Zhenzhen LI
;
Zhiyong WANG
;
Jianguo WEN
- Publication Type:Journal Article
- Keywords:
water channel;
angiogenesis;
cell migration;
cell proliferation
- From:
Basic & Clinical Medicine
2009;29(12):1334-1336
- CountryChina
- Language:Chinese
-
Abstract:
The aquaporins (AQPs) are small, integral-membrane proteins which selectively transport water across cell plasma membranes. AQPs are over-expressed in tumor cells of different origins, particularly aggressive tumors. AQPs-expressing cancer cells show enhanced migration in vitro and greater local tumor invasion, tumor cell extrava-sations, and metastases in vivo. AQPs inhibition will provide a help for tumor therapy.
