Membrane-associated guanylate kinases and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2013.09.010
- VernacularTitle:膜相关性鸟苷酸激酶与脑缺血
- Author:
Qingjie LI
;
Yun XU
- Publication Type:Journal Article
- Keywords:
Brain Ischemia;
Guanylate Kinase;
Membrane Proteins;
Receptors,N-Methyl-D-Aspartate;
Post-Synaptic Density
- From:
International Journal of Cerebrovascular Diseases
2013;21(9):711-716
- CountryChina
- Language:Chinese
-
Abstract:
Membrane-associated guanylate kinases (MAGUKs) is a class of postsynaptic density proteins (PSDs) in the postsynaptic dense of the postsynaptic membrane,including PSD-95,SAP-102,PSD-93,and SAP-97.MAGUK family members contain several protein binding sites,and these special binding sites are responsible for mediating a variety of signal transduction.MAGUKs participate in the occurrence and development mechanisms in central nervous system diseases,and has become a topic of general interest of neuroscience.This article briefly reviews the roles of MAGUKs in ischemic brain injury.