Analysis of 222 cases of acute myeloid leukemia karyotype and chemotherapeutic effect
- VernacularTitle:222例急性髓系白血病染色体核型与化疗疗效分析
- Author:
Bei LIU
;
Juan LI
;
Xuan CHEN
;
Yu JIN
- Publication Type:Journal Article
- Keywords:
karyotyping;
acute myeloid leukemia;
chemotherapeutic effect
- From:
Basic & Clinical Medicine
2010;30(1):80-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of acute myeloid leukemia kayotype with chemotherapeutic effect. Methods Conventional cytogenetic technique of G-band was used to analyze in 222 acute myeloid leukemia patients. Results Eighty-six cases (42. 1%) with cytogenetic abnormalities were found in 204 patients. Excepting for M_3 patients,the favorable,intermediate and adverse groups according for MRC criteria were treated with TA or CAG schema respectively. CR rate of M_3 was obviously higher than non-M_3. The favorable and intermediate group were obviously surpassinger than adverse group in TA schema. CR rate of the intermediate group was highter than that of other groups in CAG schema. CR rate of the adverse group in two schema were all low. CAG was surpassinger than TA schema in intermediate group. Conclusion Cytogenetics is an important chemotherapeutic and prognostic factor to acute myeloid leukemia. CAG schema could be the leader selection in the de novo presby or oligoac-crementional AML patients.
