Progress in the research of relationship between γH2AX, ATM and DNA damage by endogenous oxidants
- VernacularTitle:γH2AX和ATM与内源性氧化剂所致DNA损伤关系的研究进展
- Author:
Jin ZHAO
;
Zhong GUO
;
Jianxiu MA
- Publication Type:Journal Article
- Keywords:
endogenous oxidants;
γH-2AX;
ATM
- From:
Basic & Clinical Medicine
2010;30(4):437-441
- CountryChina
- Language:Chinese
-
Abstract:
This review describes the observations that constitutive ATM activation (CAA) and H2AX phosphoryla-tion (CHP) caused by endogenous oxidants in normal cells as well in tumor cell lines.This review also reported the findings on differences in CAA and CHP on the effects of several agents and growth conditions.
