Relationship between P2 purinoceptor subtypes and coronary heart disease
- VernacularTitle:P2嘌呤受体亚型与冠心病的关系
- Author:
Yongli NIE
;
Yuqin ZHANG
- Publication Type:Journal Article
- Keywords:
purinoceptors;
ATP;
coronary heart disease
- From:
Basic & Clinical Medicine
2010;30(4):434-436
- CountryChina
- Language:Chinese
-
Abstract:
In this article we review the relation between P2 purinoceptor subtypes and coronary heart disease (CHD).P2Y_1 ,P2Y_2 ,P2Y_(11) and P2X_7 receptors are related to inflammatory reaction in atheroselerosis plaque.P2X_3 receptor plays an important role in anginal nocuity response.P2X_4 receptor is involved in vascular remodeling and enhancement of myocardial contractility in non-infarct zone.P2Y2 and P2Y6 receptors are involved in resteno-sis.A polymorphism in P2Y_(11) receptors increase the risk of myocardial infarction.P2Y_1、P2Y_(12) and P2X_1 receptors play a role in thrombotic formation.The specific agonist and antagonist of P2 purinoceptor subtypes could be poten-tial targets for new drugs to treat CHD.
