Immune regulatory effect of masenchymal stem cells on T lymphocyte
- VernacularTitle:间充质干细胞在T细胞免疫反应中的调节作用
- Author:
Zhiqiong JIANG
;
Zhong TANG
;
Guohua YUAN
;
Jing TAN
- Publication Type:Journal Article
- Keywords:
mesenchymal stem cells;
T lymphocytes;
immunoregulation
- From:
Basic & Clinical Medicine
2010;30(5):547-549
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells(MSCs)have a unique role in immune regulation and focus to T-cells.In the mixed lymphocyte reactions,MSCs inhibit T-cells proliferation by cycle arrest,but they do not increase T-cell apoptosis and the suppress T-cell activation.In addition,MSCs can reduce CD8~+T cells and Thl cells,and simultaneously increase Th2 cells in the reaction system to suppress the inflammatory response,which may play a therapeutic effect on the T-cells mediated autoimmune diseases.
