CD152 gene polymorphisms in idiopathic childhood ischemic stroke
10.3969/j.issn.1000-3606.2013.11.003
- VernacularTitle:CD152基因多态性与儿童特发性脑卒中的关系
- Author:
Jianjun WANG
;
Liping ZOU
;
Jiuwei LI
;
Yue HUANG
;
Yuan LEI
- Publication Type:Journal Article
- Keywords:
stroke;
CD152;
single nucleotide polymorphism;
child
- From:
Journal of Clinical Pediatrics
2013;(11):1011-1014
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To explore polymorphisms of CD152 gene promoters (-1722T/C,-1661A/G) and exon1 (+49A/G) in children with idiopathic ischemic stroke and assess the association between these polymorphisms with the disease. Methods Us-ing the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, polymorphisms in the CD152 exon1 region (+49A/G) and promoter regions (-1722T/C,-1661A/G) were genotyped in 51 Han children with idiopathic ischemic stroke and 74 healthy Han children. Results The CD152 genotypes in control group and idiopathic ischemic stroke children were consistent to principle of Hardy-Weinberg Equilibrium (HWE) byχ2 test. The CD152+49GG genotypes and G allele frequency in the patients showed a signiifcant increase compared to the controls (χ2=7.053, 6.351, P<0.05). However, the CD152-1722T/C,-1661A/G genotypes and allele frequency showed no signiifcant difference between 2 groups (P>0.05). Clinical features (hemi-paresis, dysarthria, seizures, consciousness change, and preceding infections) did not show signiifcant correlation with genotypes and frequency of the CD152+49 polymorphisms in children with idiopathic ischemic stroke (P>0.05). Conclusions The CD152+49A/G polymorphisms may relate to idiopathic ischemic stroke.
