Application of systemic octreotide radioactive imaging in children with neuroblastoma：a report of 14 cases
10.3969/j.issn.1000-3606.2013.11.014
- VernacularTitle:全身奥曲肽显像在神经母细胞瘤诊断及预后判断的价值：附14例报告
- Author:
Yi ZHANG
;
Dongsheng HUANG
- Publication Type:Journal Article
- Keywords:
neruoblastoma;
octreotide;
radioactive image;
children;
chemotherapy
- From:
Journal of Clinical Pediatrics
2013;(11):1050-1053
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To evaluate the application of systemic octreotide radioactive imaging in diagnosis and follow-up for children with neruoblastoma (NB). Methods Clinical data of 14 children with NB applied systemic octreotide radioac-tive imaging from April 2006 to March 2011 were collected and analyzed. For the ifrst-visit patients, they were applied with systemic octreotide radioactive imaging at the ifrst follow-up appointment after routine treatment. And for recurrent or sus-pected recurrent cases, systemic octreotide radioactive imaging was applied before the treatment and after 2-3 weeks chemo-therapy. Results Nine of 14 patients were male and 5 were female with a median age of 4.8 years (1-10 years). According to In-ternational Neuroblastoma Staging System (INSS), 4 cases were categorized as stage 3 and 10 cases were categorized as stage 4. The uptake rate of systemic octreotide radioactive imaging in primary site or metastasis sites of 8 cases were higher than nor-mal site with positive rate of 57.14%(8/14). One case was conifrmed as false positive by treatment and imaging examination. Six cases were negative in primary site or metastasis sites with negative rate of 42.86%(6/14). One case was conifrmed as false negative via treatment and imaging examination. Therefore, the sensitivity of systemic octreotide radioactive imaging reached 85.71%(12/14). Conclusion Systemic octreotide radioactive imaging could be one of the effective methods for NB in diagno-sis, follow-up and evaluation of prognosis.
