Research on effects of radiation on hippocampus neuron and the related molecular mechanism
10.3969/J.ISSN.1672-8270.2013.11.001
- VernacularTitle:辐射对脑海马神经元的影响及其作用机制研究
- Author:
Ling GAO
;
Qingjie LIU
- Publication Type:Journal Article
- Keywords:
Radiation;
Hippocampus;
Neuron;
Nerve stem cell;
Apoptosis
- From:
China Medical Equipment
2013;(11):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of radiation on hippocampus neuron and the related damage mechanism in order to provide the theory base for treatment strategy of radiation brain injury. Methods:We looked up the scientific literature including following methods. Pregnant mice were irradiated with tritiated water, and then the contents of SOM in pars intermedia and AVP in hypothalamus of newborn mice were detected by radioimmunoassay. Pregnant rats were irradiated with tritiated water or X-ray, and the neuronal cells derived from the newborn rats were cultured. The morphology of cultured neuronal cells was compared with those of normal neuronal cells. The number of apoptotic cells in cortical fifth layer was measured by HE staining. Results:After radiation with tritiated water, the level of SOM in pars intermedia of newborn mouse and AVP content in hypothalamus content of male newborn mouse significantly increased and decreased, respectively. Radiation with tritiated water could result in the morphology change of neuronal cells and increase the percent of apoptosis cells in cortical fifth layer. Moreover, the percent of apoptosis cells in tritiated water group was higher than that in the X ray group. Conclusion: Radiation could impact on brain neuropeptide contents, and neurobehavioral, learning and memonic ability, result in the morphology change of hippocampal neurons, and induce the midbrain cells apoptosis.
