Clinical characteristics, etiology and long-term outcome of childhood epilepsia partialis continua
10.3969/j.issn.1000-3606.2013.11.004
- VernacularTitle:儿童持续性部分性癫临床特征、病因及远期转归分析
- Author:
Liming YANG
;
Qingyun KANG
;
Bo CHEN
;
Zeshu NING
- Publication Type:Journal Article
- Keywords:
epilepsia partialis continua;
clinical features;
outcome;
etiology;
child
- From:
Journal of Clinical Pediatrics
2013;(11):1015-1018
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate etiology, clinical characteristics and outcome in children with epilepsia partialis continua (EPC). Methods Sixty-three pediatric patients with EPC were retrospectively analysed. The patients aged (5.53±3.65) years old, with brain CT scans or MRIs after diagnosis, basic laboratory tests, cerebrospinal lfuid analysis and electroencephalog-raphy. The average follow-up time was (22.19±21.19) months (6-72 months). Results The median duration of EPC was 11 days (1-180 days). The causes of EPC were inlfammatory and immune-mediation (36 cases, 57.14%, Rasmussen’s encephalitis included), metabolic disorders (8 cases, 12.70%), brain structure abnormalities (5 cases, 7.94%), vascular malformation (5 cases, 7.94%), dual causes (3 cases, 4.76%), post brain surgery (2 cases, 3.17%) and cryptogenic pathogenesis (4 cases, 6.35%). Neurological dysfunc-tions were observed in 44 cases (69.84%). Age, routine cerebrospinal lfuid abnormalities, the presence of inlfammation and im-mune mediated, EPC long duration, involving the right upper extremity were the risk factors of poor prognosis. Conclusions The most common causes of childhood EPC are inlfammation and immune-mediated central nervous system diseases. Patients with early age of onset, a great tendency of longer duration of EPC and cerebrospinal lfuid abnormalities, involving the right upper ex-tremity have a poor prognosis.
