Clinical research progress in preoperative concurrent chemoradiotherapy for advanced adenocarcinoma of the stomach or gastroesophageal junction
10.3969/j.issn.1007-3969.2013.10.012
- VernacularTitle:进展期胃癌及胃食管结合部腺癌术前同期放化疗的临床研究进展
- Author:
Menglong ZHOU
;
Yanong WANG
- Publication Type:Journal Article
- Keywords:
Advanced adenocarcinoma of the stomach or gastroesophageal junction;
Clinical trials;
Preoperative concurrent chemoradiotherapy;
R0 resection;
Pathologic complete response
- From:China Oncology
2013;(10):852-856
- CountryChina
- Language:Chinese
-
Abstract:
This paper is about the clinical trials of preoperative concurrent chemoradiotherapy for advanced adenocarcinoma of the stomach or gastroesophageal junction reported in recent years. The radiation dose of most trials is 45 Gy. Chemotherapy drugs such as 5-fluorouracil, cisplatin and taxol are concurrently used as sensitizers. A number of trials have induction chemotherapy prior to chemoradiotherpy. The validity is evaluated by R0 resection rate, pathological complete response rate and overall survival rate. The safety is assessed by the adverse reaction, treatment related mortality, and its effect on postoperative complications and mortality. The results showed that preoperative chemoradiotherapy can significantly improve the R0 resection rate and benefit the prognosis of the patients. Meanwhile, the security and impact on operations of preoperative chemoradiotherapy is controllable. The recent researches are mostly in phase II, and more randomized controlled studies are needed. To fully accept the preoperative chemoradiotherapy as a standard treatment, more evidence and long-term efficacy index are indispensible.
