Evaluation of Microcirculation of Pancreatic Carcinoma Using Whole Organ CT Perfusion Imaging
10.3969/j.issn.1005-5185.2013.06.011
- VernacularTitle:全器官CT灌注成像评价胰腺癌微循环的价值
- Author:
Xiaoxuan MA
;
Huiping SHI
;
Wei GUO
;
Minxia QIAO
;
Hong FANG
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Tomography,X-ray computed;
Perfusion imaging;
Microcirculation
- From:
Chinese Journal of Medical Imaging
2013;(6):439-442
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To analyze the perfusion differences of different pancreatic diseases using the low-dose whole organ dynamic volume CT perfusion imaging, and to provide the evidence for the clinical application. Materials and Methods Twenty-eight patients suspected as pancreatic disease were applied by 640 layer volume CT perfusion imaging for the pancreas. Data were collected at the same time of bolus injection of contrast agent, then were analyzed by spatial alignment and perfusion calculation using the perfusion software. The time-density curve, blood perfusion flow diagram and tissue artery blood flow were obtained using the maximum slope method. Results Normal pancreatic tissue (n=9) blood flow was (117.04±12.05) ml/(min?100 ml), pancreatitis organizations (6 cases with acute pancreatitis and 3 cases with chronic pancreatitis) (118.67±37.18) ml/(min?100 ml), pancreatic carcinoma tissue (n=10) was (67.16±18.94) ml/(min?100 ml). There was significant difference among three groups (F=8.59, P<0.001);the difference was demonstrated in pancreatic cancer vs. normal pancreas and pancreatic cancer vs. pancreatitis group (q=3.70, P<0.05), which could be clearly demonstrated by blood perfusion flow diagram. The difference was not statistically revealed pancreatitis and normal pancreas group (q=2.91, P>0.05). The total dose of X-rays in the whole scanning process was 21.5-23.9 mSv. Conclusion Low-dose whole pancreas organ CT perfusion scan can quantitatively analyze the hemodynamic changes in pancreatic disease, which be of great value for evaluating changes in microcirculation during the treatment of pancreatic cancer.
