Advances of the LHX3 and LHX4 LIM-homeodomain transcription factors
10.3760/cma.j.issn.1673-4408.2013.05.022
- VernacularTitle:LIM同源结构域转录因子LHX3与LHX4的研究进展
- Author:
Limin WANG
;
Guiling LI
- Publication Type:Journal Article
- Keywords:
LHX3;
LHX4;
Structure;
Function;
Expression;
Mutation
- From:
International Journal of Pediatrics
2013;40(5):518-521
- CountryChina
- Language:Chinese
-
Abstract:
The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland.Nervous system developments play certain roles in some cancers,leukemia,and deafness disease.Mutations in the genes encoding these regulatory proteins are closely associated with combined hormone deficiency diseases in human and animal models,and related to nervous system defect,tumors,leukemia and deafness.Analysis of these diseases and the biochemical properties of the LHX3 and LHX4 protein will facilitate a better understanding of the pathogenesis of these diseases.LHX3 and LHX4 are reviewed in this paper.
