Study on relativity of genetic variants of rs 12425791 on chromosome 12p13 and prognosis in patients with acute ischemic stroke

VernacularTitle:染色体12p13的rs12425791位点基因多态性与急性缺血性卒中短期预后的关系
Author: Zhengyu CAO
Publication Type:Journal Article
Keywords: genotype; polymorphism,single nucleotide; mononucleotide; acute ischemic stroke; chromosome 12p13
From: Chongqing Medicine 2013;(33):4004-4006
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between genetic variants of rs 12425791 on chromosome 12p13 and the one year risk of stroke-related death or recurrent stroke following initial stroke .Methods A total of 401 acute ischemic stroke(AIS) patients who had first-ever ischemic stroke were analyzed .The genotypes of chromosome 12p13 rs12425791 were analyzed by PCR-RFLP .Logistic regression analysis was used to assess the effect of individual genotype on stroke-related mortality or recurrent stroke in one year .Results Among the 401 AIS patients ,31 died or developed a recurrent stroke .After adjustment for age ,sex and vascular risk factors ,logistic regression analysis indicated that the odd ratio were 2 .602(95% CI 1 .216-5 .564) for individuals with homozygous variant allele of rs12425791 .Conclusion This study found that genetic variants of rs12425791 on chromosome 12p13 are independent predictors of stroke-related mortality or stroke recurrence in patients with incident ischemic stroke .