The efficacy and side effect of fentanyl transdermal system in the treatment of intractable postherpetic neuralgia in 30 cases

VernacularTitle:芬太尼透皮贴剂用于30例难治性PHN的疗效及不良反应
Author: Ying SHI ; Fachuan NIE ; Suxia WANG
Publication Type:Journal Article
Keywords: herpes zoster; neuralgia; fentanyl; analgesia; side effect
From: Chongqing Medicine 2013;(33):4026-4027
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effects of fentanyl transdermal system on intractable postherpetic neuralgia .Methods 30 patients(after 1 course of conventional drugs with nerve block therapy ,VAS score>5 points)were randomly divided into tramadol group(group T ) and fentanyl group(group F) ,15 cases in each group .Results VAS of the two groups decreased after treatment (P<0 .05) ,group F decreased more significantly(P<0 .05) .The quality of life scores after treatment in two groups were signifi-cantly increased(P<0 .05) ,group F scoring was higher(P<0 .05) .The incidence of side reaction ,nausea and vomiting was lower in group F(P>0 .05) .The incidence of dysuria was 26 .67% in group T ,and there was no dysuria in group F(P<0 .05) .Constipation of group T was 40% after treatment(P<0 .05) .The incidence of somnolence of group F was higher than T group(P<0 .05) .The two groups were no respiratory depression .Conclusion Fentanyl transdermal system for intractable postherpetic neuralgia has good analgesic effect ,less side effect ,and well-tolerated .