Role of ILK in the dysfunction of myocardium contraction following hemorrhagic shock
10.3969/j.issn.1671-8348.2013.33.002
- VernacularTitle:失血性休克大鼠心肌收缩功能障碍中整合素联接激酶的作用
- Author:
Yuqiang FANG
;
Tao LI
;
Yu ZHU
;
Liangming LIU
- Publication Type:Journal Article
- Keywords:
shock,hemorrhagic;
papillay muscle;
integrin-linked kinase;
myocardial systolic function
- From:
Chongqing Medicine
2013;(33):3980-3982
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of ILK on myocardium contraction following hemorrhagic shock .Methods With iso-lated cardiac papillary muscle and isolated heart ,the contraction of papillary muscle and hemodynamic parameters (left intraventricu-lar systolic pressure(LVSP) ,the maximal change rate of left intraventricular pressure were measured .Results Compared with nor-mal control hearts ,ILK activity ,contractile response of cardiac papillary muscle and hemodynamic parameter were decreased signifi-cantly gradually in shock heart at the 1 ,2 h(P<0 .05) ,and the change of ILK activity was positive correlative with contractile re-sponse and hemodynamic parametert .With ILK agonist [phosphatidylinositol(3 ,4 ,5)trisphosphate ,PLTP] the dysfunction of con-tractile response and hemodynamic parameter could be improved significantly (P<0 .05) ,while these improvement could be abol-ished by ILK specific inhibitor(P<0 .05) .Conclusion ILK play important role in the regulation of cardiac contractility following hemorrhagic shock .
