Expression changes of HSP90α in cardiac muscles in rats with severs hemorrhagic shock by the treatment of different resuscitating fluid
10.3969/j.issn.1671-8348.2013.32.032
- VernacularTitle:复苏液体对重度失血性休克大鼠心肌热休克蛋白90α表达的影响
- Author:
Xiaokun YANG
;
Mingyuan XU
;
Guisen XU
- Publication Type:Journal Article
- Keywords:
resuscitating fluids;
hemorrhagic shock;
heat shock proteins 90α
- From:
Chongqing Medicine
2013;(32):3932-3934
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression changes of HSP90αin cardiac muscles and survival rates in rats by using the different fluids to resuscitate the severs hemorrhagic shocked rats ,and provide reference for the clinical treatment of hemorrhagic shock with different resuscitation fluids .Methods Uncontrolled hemorrhagic shock rats model was established ,using lactic acid salinger liquid ,poly peptide injection gelatin ,hypertonic sodium chloride dextran for fluid resuscitation respectively ,and then checked the HSP90αexpression changes and survival rates in rats .Results the expressions of HSP90αin myocardial tissue and the mortality in rats were different after using different resuscitation fluids in severe hemorrhagic shock rats ,difference was statistically significant(P<0 .05) .Conclusion the expression of HSP90α in cardiac muscles of rats could be induced by severe hemorrhagic shock ,the HSP90αexpressed differently and regularly after using different resuscitating fluids ,it implied that the HSP90α played an important role in the hemorrhagic rats cardiac as a regulating fator .
