The change of NK or NKT cells in the peripheral blood of patients with HBV-associated acute-on-chronic liver failure
10.3969/j.issn.1671-8348.2013.31.009
- VernacularTitle:NK 与NKT 细胞在慢加急性肝衰竭患者外周血中的变化分析
- Author:
Hui PENG
;
Lin CHANG
;
Lei WANG
;
Min CHEN
- Publication Type:Journal Article
- Keywords:
kills cells,natural;
NKT;
acute-on-chronic liver failure;
hepatitis B virus
- From:
Chongqing Medicine
2013;(31):3747-3749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change in the proportion of NK or NKT cells in the peripheral blood of patients with HBV associated acute-on-chronic liver failure(HBV-ACLF) .Methods the frequency of NK or NKT cells in the blood of 25 healthy controls(HC) ,40 patients with chronic hepatitis B(CHB) and 26 HBV-ACLF patients was detected by flow cytometry .The differ-ences in the proportion of NK and NKT cells among the three groups were analyzed by SPSS software and the correlation was ana-lyzed between the frequence of NK or NKT cells and HBV markers and the level of liver function .Results the proportion of NK cells in HC ,CHB ,or HBV-ACLF group was (15 .0 ± 6 .0)% ,(11 .4 ± 6 .8)% ,(8 .9 ± 6 .7)% respectively ,and the difference be-tween the HBV-ACLF group and HC or CHB group was statistically significant (P<0 .05) .And for the NKT cells ,its frequence in the HC ,CHB ,or HBV-ACLF group was (1 .9 ± 1 .3)% ,(4 .3 ± 3 .7)% ,(5 .4 ± 8 .6)% respectively ,and there was significant difference between the HBV-ACLF group and HC group(P<0 .05) .Conclusion The proportion of NK cells in HBV-ACLF has a significant decline ,while NKT cells has a significant increases .it indicate that NK or NKT cells might be play a certain role in the HBV-ACLF development process .
