Review on Stem Cells Used on Heart Regeneration
- VernacularTitle:干细胞用于心脏再生的研究进展
- Author:
Li WU
;
Weitutor MAO
- Publication Type:Journal Article
- Keywords:
cardiac stem cells;
hematopoietic stem cell;
muscle celldedifferentiation;
celltherapy;
cardiac regeneration
- From:
Journal of Zhejiang Chinese Medical University
2013;(11):1360-1362
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] This article mainly discussed the potential of myocardial cellregeneration and the possible mechanisms involved. [Method] To study the mechanism of cardiac regeneration ability HSCs, this review studyed the relationship of the differentiation of cardiac stem cells, hematopoietic stem cells, myocardial cells and myocardial regeneration and the possible mechanisms involved. [Result] Self-renewing, differentiation both in vitro and in vivo of the c-kit positive CSCs had been seen. No matter in physiological condition or after damage, the c-kit positive CSCs had clonality and the potential of multi-directional differentiation. Hematopoietic stem cells can generate cardiomyocytes and coronary blood vessels for human celltherapy. The ability of dedifferentiation cells to maintain and improve the ventricular function of a damaged heart is very limited. [Conclusion] CSCs and HSCs play an important role in reversing chronic ischemic and non-ischemic heart failure.
