The association between polymorphism of parathyroid hormone gene and bone mineral density in Fuzhou postmenopausal women
10.3969/j.issn.2095-4344.2013.50.004
- VernacularTitle:绝经后妇女甲状旁腺素基因多态性与骨密度：福州地区的调查
- Author:
Lihua XIE
;
Chenbo NI
;
Shengqiang LI
;
Juan CHEN
;
Huijuan XU
;
Yulian LAI
;
Jirong GE
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2013;(50):8641-8646
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Studies have shown the bone mineral density of postmenopausal women is closely related to parathyroid hormone. But there are differences in different areas.
OBJECTIVE:To investigate the association between BstBⅠ polymorphism of parathyroid hormone gene with bone mineral density in postmenopausal women from Fuzhou area.
METHODS:The bone mineral densities of the lumbar spine, femoral neck, trochanter and Ward’s triangle were measured in 150 postmenopausal women by dual energy X-ray absorptiometry. The genotype of parathyroid hormone gene was determined by polymerase chain reaction-restriction fragment length polymorphism.
RESULTS AND CONCLUSION:(1) The distribution of parathyroid hormone genotypes were BB genotype 68.8%, Bb 24.1%, and bb 7.1%. The B al elic gene frequencies reached 81%, while b was 19%. The distribution fol owed the Hardy-Weinberg equilibrium. (2) Analysis of the relationship between the genotypes and bone mineral density:There was no significant difference in the bone mineral densities of the lumbar spine, femur, neck, trochanter and Ward’s triangle among the three genotypes (P>0.05). BstBⅠ gene polymorphism of parathyroid hormone gene is not correlated to bone mineral density, and there is no enough evidence to support genotype of parathyroid hormone gene as a genetic marker in predicting the risk of developing osteoperosis in Fuzhou postmenopausal women.
