Association of angiotensinogen gene M235T polymorphisms with essential hypertension：a meta-analysis
10.3969/j.issn.1671-8348.2013.31.013
- VernacularTitle:血管紧张素原基因M235T多态性与原发性高血压相关性的Meta分析
- Author:
Xuming ZHU
;
Guoqiang XIE
;
Jian ZHANG
;
Weifeng SUN
;
Guoqian CHEN
- Publication Type:Journal Article
- Keywords:
meta-analysis;
essential hypertension;
polymorphism,genetic;
angiotensinogen
- From:
Chongqing Medicine
2013;(31):3759-3763
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association of angiotensin (AGT ) gene M235T polymorphism with essential hypertension (EH) .Methods The literatures examining the association of the M 235T polymorphisms with EH were selected in electronic data-bases .Using RevMan5 .0 ,heterogeneity and pooled effect sizes were calculated .Results Totally ,29 articles ,with 5 971 cases and 6 443 controls were finally included in this study .The odds ratio (OR) value of TT+ TM∶MM genotype was 1 .13 (95% CI 1 .00-1 .25 ,P=0 .04) in worldwide populations .Subgroup analysis showed that the OR values of TT ∶MM genotype were 1 .13 (95% CI 0 .90-1 .42 ,P=0 .28) in subjects published before 2008 and 1 .29(95% CI 0 .94-1 .75 ,P=0 .11) in those after 2008(year of 2008 included) .The OR values of T ∶M in Han population was 1 .24 (95% CI 1 .01-1 .53 ,P=0 .04) .Conclusion TT+ TM genotype of the M235T polymorphisms is associated with EH in worldwide populations ,and T allele is also correlated with EH in Han popu-lation .
