A Comparative Study of Aripiprazole and Risperidone in the Treatment of Alzheimer’s Disease Dementia Combined Psychiatric Symptoms
- VernacularTitle:阿立哌唑与利培酮治疗阿尔兹海默病性痴呆精神症状的临床对照
- Author:
Donghui HU
;
Ajing WANG
- Publication Type:Journal Article
- Keywords:
Aripiprazole;
Risperidone;
Alzheimer’s disease;
Psychiatric symptoms
- From:
Journal of Kunming Medical University
2013;(12):114-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and compare the therapeutic effect of aripiprazole and risperidone in the treatment of psychiatric symptoms in Alzheimer’s disease dementia. Methods 64 patients of Alzheimer's disease dementia with psychiatric symptoms,were divided into risperidone donepezil group (A) and aripiprazole donepezil group (B ) . Before and 4, 8 weeks after treatment, the BEHAV-AD scale was used to assess the pathological behavior and the side effects scale (TESS) was used to assess adverse drug reactions.Results A group at 4 weeks after treatment BEHAV-AD score showed no significant difference with before treatment ( >0.05), 8 weeks after treatment decreased significantly (<0.05) . Group B 4 weeks and 8 weeks after treatment BEHAV-AD score was significantly decreased ( <0.05) . BEHAV-AD score in Group B 4 weeks and 8 weeks after treatment was significantly lower than group A ( <0.05) .The scores in behavioral disorders, depression, anxiety in Group B were significantly lower than group A ( <0.05), the scores in paranoia ,hallucinations,aggressive behavior, delirium showed no significant difference between two groups ( >0.05) . 4 weeks after treatment,the two groups had no significant difference in TESS score ( >0.05), 8 weeks after treatment the TESS scores in group B were significantly lower in group A ( <0.05) .Conclusion Aripiprazole + donepezil can effectively alleviate the symptoms of these patients with lower mental side effects, and has better effect in treatment of Alzheimer's disease dementia with psychiatric symptoms.
