The Research Progress of Herceptin in Treatment of HER-2 Overexpressing Breast Cancer
- VernacularTitle:曲妥珠单抗1治疗HER-2过表达乳腺癌的研究进展
- Author:
Xianyu CHEN
;
Kunhua WANG
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Her-2 gene;
Herceptin;
Targeted therapy
- From:
Journal of Kunming Medical University
2013;(12):145-148
- CountryChina
- Language:Chinese
-
Abstract:
Oncogene activation and inactivation of tumor suppressor genes is an important molecular mechanism of tumor formation. HER-2 oncogene is associated with breast cancer invasion and metastasis and prognosis, HER-2 overexpressing breast cancer progresses rapidly and has poor prognosis. In recent years, the emergence of targeted therapeutic monoclonal antibody drug Herceptin which built its structure for the HER-2 has significantly inproved HER-2-positive advanced breast cancer.
