Effect of long-distance anti-inflammation induced by antidromic electronic stimulation of unilateral dorsal root on rats
- VernacularTitle:逆向电刺激大鼠单侧脊神经背根产生远距离抗炎效应
- Author:
Jun WANG
;
Mingliang CHEN
;
Shaojie MA
;
Yuan GUO
- Publication Type:Journal Article
- Keywords:
dorsal root;
antidromic electronic stimulation;
inflammation;
cross excitation;
formalin
- From:
Acta Universitatis Medicinalis Anhui
2013;(12):1461-1465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the anti-inflammation effect of antidromic electronic stimulation of rat dorsal roots. Methods Cross-excitation between adjacent primary afferent fibers and subcutaneous injection of 2% FM were adopted here as two inflammatory models. The firing rate and mechanical threshold of single units after cross-excitation were collected. The phosphorylated cAMP response element binding protein (p-CREB) level in spinal cord induced by formalin was visualized with immunohistology. Results Antidromic electronic stimulation (ADES) of dorsal roots could significantly inhibit the p-CREB over expression to FM injected in the contralateral hindpaw, and the increase in firing rate and mechanical threshold induced by cross-excitation were also inhibited by the ADES. Conclusion Antidromic electronic stimulation of the dorsal root may produce a systemic anti-inflamma-tion capacity.
