The changes of bone resorption in prednisone treatment of nephrotic syndrome and the intervention of α-D3 on it
- VernacularTitle:泼尼松治疗肾病综合征骨吸收的变化及α-D3的干预作用
- Author:
Xueping WU
;
Li HAO
;
Guiling LIU
- Publication Type:Journal Article
- Keywords:
nephritic syndrome;
deoxypyridinoline;
prednisone;
bone resorption;
α-D3
- From:
Acta Universitatis Medicinalis Anhui
2013;(12):1530-1532
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the change of bone resorption of primary nephrotic syndrome (PNS) patients with prednisone treatment, andα-D3 effects on it. Methods ①30 PNS patients diagnosed and 28 healthy people in our hospital were selected;blood and urine samples before and after enough prednisone (pred) treatment were collect-ed to detect the iPTH, calcium and urinary DPD. ②30 PNS patients after 6 weeks enough prednisone treatment were randomly divided into Pred +α-D3 group and Pred group. Results ① PNS group compared with healthy group, urine DPD excretion rate was significantly increased(P<0.05),and blood iPTH was significantly increased (P<0.01);blood calcium was similar to healthy group. ② PNS patient after treatment with pred compared with that before treatment, urine DPD excretion rate was significantly increased(P<0.01),and blood iPTH was signifi-cantly increased(P<0.01). There was no obvious change in blood calcium.③Pred+α-D3 group compared with Pred group, urine DPD excretion rate was significantly decreased(P<0.01),and blood iPTH was significantly de-creased(P<0.05). There was no obvious change in blood calcium. Conclusion α-D3 can effectively reduce bone resorption in PNS patients.
