MicroRNA-mediated Tumor Multidrug Resistance and Function of Traditional Chinese Medicine
10.11842/wst.2013.07.005
- VernacularTitle:microRNA介导肿瘤多药耐药及中药的作用
- Author:
Ruijuan ZHANG
;
Jianhua XU
;
Wenyan YU
;
Guojuan WANG
;
Jue SUN
;
Zhongze FAN
- Publication Type:Journal Article
- Keywords:
MicroRNA;
multidrug resistance;
tumor;
review
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(7):1515-1520
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA for short) can induce mRNA cleavage or inhibit mRNA translation and regulate gene expression in the post-transcriptional level, which involves cell development, proliferation, differentiation, apoptosis, and a series of important biological processes. Recent studies have found that the abnormal regulation of miRNA's target genes may be involved in tumor resistance. And it is expected to become important tumor resistance-associat-ed molecular markers and therapeutic targets. Mechanism of traditional Chinese medicine (TCM) and its active ingre-dients can affect miRNA to regulate target proteins and target genes mediated tumor multidrug resistance. It can pro-vide new ideas for the mechanism of reversing multidrug resistance by TCM.
