Motor Learning Induces c-fos Expression in Mouse Cerebellum.
- Author:
Man Ho KIM
1
;
Beom S JEON
Author Information
1. Department of Neurology, College of Medicine, Seoul National University, Korea.
- Publication Type:Original Article
- MeSH:
Animals;
Cerebellum*;
Gene Expression;
Learning*;
Memory;
Mice*;
RNA, Messenger
- From:Journal of the Korean Neurological Association
1994;12(3):518-526
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE. To examine whether cerebellum participates in motor learning and expresses immediate early gene during motor learning. BACKGROUND. There are increasing evidences that cerebellum plays a role in motor learning. Motor learning such as skill is one of long term memory that produces structural changes associated with immediate early gene expression. METHODS. We destructed mouse cerebellum surgically and compared the motor performance with normal control by using Rota-Rods test. Motor performance was tested on repeated trials to measure learning. We also measured the c-fos mRNA level in the cerebellum at 0, 30, 60 and 120 minutes of motor learning experiment. RESULTS. Motor learning is impaired in the mice with cerebellar lesion. C-fos mRNA level increased in the cerebellum at 30 and 60 minutes during motor learning.
