Experimental Studies on Hemostatic Effect and Hemostatic Mechanism of Water Decoction of Blumea Megacephala (Randeria) Chang et Tseng
10.11842/wst.2013.07.011
- VernacularTitle:壮药白花九里明水煎液止血作用机制探讨
- Author:
Yan HUANG
;
Xiaoqing NING
;
Xianling YUAN
;
Xiajun ZHONG
;
Yuanfeng TAN
;
Fen QIU
;
Yingbo LIN
- Publication Type:Journal Article
- Keywords:
Blumea megacephala (Randeria) Chang et Tseng;
hemostatic effect;
mechanism of action;
glass slides method;
capillary tube method;
tail-cutting method
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(7):1552-1556
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to evaluate the hemostatic effect and mechanism of action for water decoction of Blumea megacephala (Randeria) Chang et Tseng in order to understand its influence to the liver function. The glass slides method and capillary tube method were used in the measurement of the coagulation time (CT). And the tail-cutting method was used to measure the bleeding time (BT), prothrombin time (PT), activated part clotting live en-zyme time (APTT), thrombin time (TT), content of plasma fibrinogen (FIB), platelet count (PLC), plasma complex cal-cium time (PRT), alanine aminotransferase (ALT) and aspartate transaminase (AST). The results showed that intragastric administration with different doses of water decoction of Blumea megacephala (Randeria) Chang et Tseng (6.7 g·kg-1, 13.4 g·kg-1, 26.8 g·kg-1) can reduce CT and BT of mice. And intragastric administration with different doses of wa-ter decoction of Blumea megacephala (Randeria) Chang et Tseng (4.7 g·kg-1, 9.4 g·kg-1, 18.9 g·kg-1) can produce different degrees of impact on PT, APTT, TT and PRT of rats. Certain dose of water decoction of Blumea megacepha-la (Randeria) Chang et Tseng can reduce ALT and AST. It was concluded that Blumea megacephala (Randeria) Chang et Tseng had the hemostatic effect and its mechanism of action may be through the activation of the intrinsic and extrinsic coagulation system. There was no obvious damage to the liver.
