Overview of Antitumor Effects and Mechanism of Ginsenoside Rb1, Rg3, Rh2

VernacularTitle:人参皂苷Rb1、Rg3、Rh2抗肿瘤作用与机制概况
Author: Weiwei JIANG ; Jia LIU
Publication Type:Journal Article
Keywords: Ginsenoside Rb1; Ginsenoside Rg3; Ginsenoside Rh2; antitumor effects; mechanism
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(7):1634-1637
CountryChina
Language:Chinese
Abstract: Ginsenoside is the main component of antitumor effects of traditional Chinese medicine (TCM) Ginseng. Clinical pharmacological studies have shown that Ginsenoside Rb1 can inhibit P-gp which can lead to efflux of drugs, enhance the sensitivity of cells to drugs, reduce the multidrug resistance of the tumor cell, and maintain the immune function of the body to tumor cells. Ginsenoside Rg3 can impact tumor cell protein expression, play a role in cell division, induce tumor cell apoptosis and inhibit tumor growth of blood vessels. Ginsenoside Rh2 may play an antitumor effect by inhibiting tumor cell proliferation and metastasis, inducing tumor cell apoptosis. This article ex-plained the antitumor effects and mechanism of Ginsenoside Rb1, Rg3, Rh2 in order to provide theoretical evidences for the clinical development and application.