Optimization on Preparation Techniques of Wuji Gastric Floating Sustained-release Tablets by Multicomponent Indicator

VernacularTitle:多指标优化戊己胃内漂浮型缓释片制备工艺研究
Author: Qun WANG ; Wen LIU ; Daye CHEN ; Song YANG ; Xiaowei SHI
Publication Type:Journal Article
Keywords: Wuji Gastric Floating Sustained-release Tablets; gastric floating; orthogonal design; multicomponent release rate
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(7):1638-1643
CountryChina
Language:Chinese
Abstract: This study was aimed to screen out an optimal pharmaceutical formulation of Wuji Gastric Floating Sus-tained-release Tablets. With multicomponents of release for index, the extra-floating ability of the tablets was stud-ied with the orthogonal test of four excipients, which were HPMC (K100M), PEG 6000, sodium bicarbonate and se-tanol. The results showed that the combined optimal pharmaceutical formulation was 35% HPMC, 5% PEG 6000, 10% sodium bicarbonate, 15% setanol, 10% MCC and 25% main drug. It was concluded that Wuji Gastric Floating Sustained-release Tablets had the characteristics of slow-release and long floating duration which comply with re-quirements of formulation design. This preparation technique is with good maneuverability.