Uncertainty of Syndrome-attribution Determination among Animal Models Based on Symptoms Differentiation and Drug Reduction
10.11842/wst.2013.07.034
- VernacularTitle:基于症状辨证和药物反证判定造模动物证属性的不确定性
- Author:
Ying FAN
;
Maoxin LIANG
- Publication Type:Journal Article
- Keywords:
Animal model;
signs and symptoms differentiation;
drug reduction;
syndrome-attribution of animal models;
question
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(7):1670-1675
- CountryChina
- Language:Chinese
-
Abstract:
Syndrome attribute determined by signs and symptoms of an animal model through intervening in the clini-cal and animal syndrome differentiation standards is not standardized, objective or rigorous. The signs and symptoms of people are difficult to be expressed fully and accurately in the animal body correspondingly. The signs and symptoms of animals are mostly without any syndrome information. There are no difference of signs and symptoms among differ-ent modeling methods. Hence, it is difficult to determine the syndrome-attribution of an animal model based on signs and symptoms. There are two problems in drug reduction to determine syndrome-attribution of animal models. Firstly, for drug reduction, only one group is used in the animal subject. There are no other two groups or multi-groups of drugs compared with each other to confirm the syndrome-attribution of animal models. Lots of research results indicat-ed that multiple drugs with different functions can change the state and the objective index of the same animal subject. Secondly, employing the control principle, adjusting and improving the best drug for the animal subject were used to determine the syndrome-attribute. However, these studies cannot be operated, because the preliminary studies, such as the essence of syndrome, have not provided generally recognized effect indexes and index groups.
