Clinical Experience of Subacute Sclerosing Panencephalitis treated with Alpha-interferon and Ionsiplex.
- Author:
Sang Chan LEE
1
;
Sung Hun LEE
;
Sun Ki RHO
;
Kyu Hyun PARK
;
Sang Wook KIM
Author Information
1. Department of Neurology, Pusan National University, Korea.
- Publication Type:Case Report
- MeSH:
Antibodies;
Central Nervous System;
Cerebrospinal Fluid;
Child;
Electroencephalography;
Hemagglutinins;
Humans;
Inosine Pranobex;
Interferon-alpha*;
Measles;
Measles virus;
Subacute Sclerosing Panencephalitis*;
Young Adult
- From:Journal of the Korean Neurological Association
1994;12(3):542-551
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Subacute sclerosing panencephalitis (SSPE) is a slowly progressing, chronic persistent fatal central nervous system disease, involving gray and white matter, especially white matter caused by measles virus that affecting children and young adult. 45 to 68% of affected individuals had measles before the age of 2. Current knowledge of the pathogenesis of SSPE involves mutation of the measles virus, resulting in lack of production of the M(Matrix)-protein. No therapeutic maneuvour gas been proven conclusively to be of value. But recently intraventricular alpha-interferon (a-IFN) injection combined with oral inosiplex increase the length of survival and may bring remission or stabilization in SSPE. We report a case of SSPE which was diagnosed by history, clinical manifestation, typical EEG findings, high titer of measles antibodies in cerebrospinal fluid and serum by hemagglutinin inhibition method. We tried intraventricular a-IFN injection via Ommaya reservoir and oral inosiplex.
