Chemokine CXCL12 and cancer
10.3760/cma.j.issn.1673-422X.2013.09.003
- VernacularTitle:趋化因子CXCL12与肿瘤
- Author:
Taicheng ZHAO
;
Ying BAI
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Cell proliferation;
Neoplasm metastasis;
Neovascularization,pathologic
- From:
Journal of International Oncology
2013;40(9):649-652
- CountryChina
- Language:Chinese
-
Abstract:
CXCL12,also known as stromal cell-derived factor 1,is a member of the CXC family,which locates on the 10th chromosome and produces by the stromal cells.It is known that CXCR4 and CXCR7 are the two receptors of chemokine CXCL12.Many studies show that the chemokine CXCL12 plays an important role in cancer progression,including proliferation,metastasis and angiogenesis.Therefore,the chemokine CXCL12 is expected to become a novel target for the gene therapy of cancer.
