Research advancement in lymphangiogenesis in renal cell carcinoma
10.3969/j.issn.1000-8179.20130986
- VernacularTitle:肾癌的淋巴管新生研究进展
- Author:
Xiuming LI
;
Man YU
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
lymphangiogenesis;
vascular endothelial growth factor-C;
vascular endothelial growth factor receptor-3
- From:
Chinese Journal of Clinical Oncology
2013;(22):1412-1414
- CountryChina
- Language:Chinese
-
Abstract:
Renal cell carcinoma (RCC) is a common urologic malignancy, comprising 2% to 3% of all malignant diseases. Lym-phangiogenesis significantly affects the lymphatic metastasis of tumors. Vascular endothelial growth factors and their receptors have important functions in the spread of cancer cells. Vascular endothelial growth factor-C, which links the vascular endothelial growth factor receptor-3, can increase lymphangiogenesis and promote lymphatic metastasis. These findings direct research efforts toward lymphangiogenesis in malignant diseases and a possible targeted therapy. An increasing number of studies on the lymphatic vessel of renal cell carcinoma have drawn considerable interest in the treatment of renal cell carcinoma. This paper summarizes recent studies on lymphangiogenesis and the clinical significance of renal cell carcinoma.
