Role of NKG2D ligand on NK cell immunotherapy in advanced esophageal cancer patients after operation
10.3969/j.issn.1000-8179.20130898
- VernacularTitle:NKG2D配体在中晚期食管癌患者术后NK细胞免疫治疗中的作用
- Author:
Zhifeng ZHOU
;
Shuoyan LIU
;
Qingfeng ZHENG
;
Jieyu LI
;
Mingshui CHEN
;
Feng WANG
;
Xiaofeng CHEN
;
Yunbin YE
- Publication Type:Journal Article
- Keywords:
natural killer cell;
esophageal cancer;
NKG2D
- From:
Chinese Journal of Clinical Oncology
2013;(22):1373-1377
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of NKG2D ligand MHC-I related molecule A (MICA) in chemotherapy combined with NK cell immunotherapy in patients with advanced esophageal cancer after surgery. Methods:A total of 90 patients with esophageal cancer from Fujian Provincial Tumor Hospital were divided into three groups after surgery:40 patients of chemotherapy alone, 25 patients of chemotherapy combined with NK cell therapy with negative expression of MICA (MICA-group), and 25 patients of chemotherapy combined with NK cells therapy with positive expression of MICA (MICA+group). The efficacy was then compared. Results:Compared with the chemotherapy alone and MICA-groups, the positive rates of CD3+, CD4+T cells, NK cells, and the CD4+/CD8+ratio in peripheral blood from MICA+group were higher than those before treatment (64.2%± 6.4%vs. 51.3%± 5.6%, 39.8%± 8.2%vs. 29.5%± 3.2%, 25.3%± 2.1%vs. 16.4%±4.3%, 1.4%± 0.5%vs. 1.1%± 0.7%;P<0.05). Meanwhile, the levels of T-reg cells were lower than those before treatment (6.3%± 4.5%vs. 17.3%± 2.4%, P<0.05). No significant difference was observed between the disease control rate and response rate. Chemotherapy-induced neutropenia and peripheral neurotoxicity symptoms were significantly improved, and time to progression (TTP) and overall survival (OS) were significantly prolonged (P<0.05). No statistically significant difference was observed between the chemotherapy alone group and MICA-group (P>0.05). Conclusion:Treatment with chemotherapy and autologous NK cells on patients with advanced esophageal carcinoma and MICA positive expression can be safely transfused with only minor side effects and can effectively improve a patient's immune system, quality of life, and survival.
